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Real-World Persistence, Adherence, Hypoglycemia, and Health Care Resource Utilization in People With Type 2 Diabetes Who Continued With the Second-Generation Basal Insulin Analog Insulin Glargine 300 Units/mL or Switched to a First-Generation Basal Insulin (Insulin Glargine 100 Units/mL or Detemir 100)
- Source :
- Clinical Diabetes; Summer2023, Vol. 41 Issue 3, p425-434, 10p
- Publication Year :
- 2023
-
Abstract
- People with type 2 diabetes receiving a second-generation basal insulin (BI) analog may be switched to a first-generation formulation for financial reasons or changes in health insurance. However, because second-generation BI analogs have more even pharmacokinetic profiles, longer durations of action (>24 vs. ≤24 hours), and more stable action profiles than first-generation BI analogs, such a change may result in suboptimal treatment persistence and/or adherence. This study compared treatment persistence, treatment adherence, rates of hypoglycemia, and health care resource utilization outcomes in people with type 2 diabetes who either continued treatment with the second-generation BI Gla-300 or switched to a first-generation BI. The study showed that continuing with Gla-300 was associated with a lower risk of discontinuing therapy, fewer emergency department visits, and lower hypoglycemia event rates than switching to a first-generation BI. [ABSTRACT FROM AUTHOR]
- Subjects :
- CLINICAL drug trials
THERAPEUTICS
SCIENTIFIC observation
HOSPITAL emergency services
INSULIN derivatives
RETROSPECTIVE studies
ACQUISITION of data
TYPE 2 diabetes
MEDICAL care use
TREATMENT effectiveness
RISK assessment
HYPOGLYCEMIA
PSYCHOSOCIAL factors
MEDICAL records
PATIENT compliance
PEOPLE with diabetes
DISEASE risk factors
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 08918929
- Volume :
- 41
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Clinical Diabetes
- Publication Type :
- Academic Journal
- Accession number :
- 164816087
- Full Text :
- https://doi.org/10.2337/cd22-0096