Study on effect of lactic acid bacteria on gout symptoms in rats.

The study used mixed plants such as Purslane and Tartary buckwheat as substrates, to investigate the effect of fermented Chinese medicine liquid on serum biochemical indexes and pathological morphology of kidney and ankle synovium in gouty arthritis rats. Sixty male Kunming rats were randomly divided into six groups, with 10 rats in each group by using UPLC-MC/MC technique. The rats in blank control group were fed with normal diet, and the other groups were fed with 2% potassium oxazinate combined with 12% yeast paste special diet. After 4 w, blank control group and model control group were intragastrically given normal saline, and low concentration fermentation solution group, medium concentration fermentation solution group and high concentration fermentation solution group were intragastrically given 20%, 40% and 60% fermented Chinese medicine liquid, respectively, with the intragastrically given 16 mL/kg. The experiment lasted for 3 w. The results showed that there were 55 kinds of flavonoids in the fermentation broth, the relative content of which accounted for 15.39%. In animal experiments, compared with model control group, serum UA, BUN, Cr and TNF- α content of rats in high concentration fermentation liquid group were extremely decreased (P<0.01). The histopathologic sections of synovium of kidney and ankle showed that fermented Chinese medicine liquid could improve the injury of kidney tissue and ankle inflammation in rats with gouty arthritis. The study indicates that fermented Chinese medicine liquid has a certain protective effect on kidney injury caused by high uric acid, and has a certain antiinflammatory effect on rats with gouty arthritis, and the effect of high concentration is the most obvious. [ABSTRACT FROM AUTHOR]