FBXO22 promotes cell proliferation and inhibits autophagy in HPV-associated cervical cancer by inactivating the LKB1/AMPK pathway.

Background: Cervix cancer (CC) is the most common gynecological malignancy and the leading cause of morbidity in women around the world. Objectives: In this research, the effect of FBXO22 on HPV-associated CC was evaluated. Results: The results first illuminated that FBXO22 was highly expressed in HPV⁺ CC patients. FBXO22 knockdown inhibited the proliferation of HPV⁺ CC cells, and promoted autophagy in HPV⁺ CC cells. Finally, FBXO22 regulates the LKB1/AMPK pathway. Conclusion: This research hinted that FBXO22 promotes cell proliferation and inhibits autophagy in HPV-associated CC by inactivating the LKB1/AMPK pathway. [ABSTRACT FROM AUTHOR]