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Mannose-binding lectin (MBL) levels in children with Hashimoto's thyroiditis.
- Source :
- Northern Clinics of Istanbul; 2023, Vol. 10 Issue 3, p353-358, 6p
- Publication Year :
- 2023
-
Abstract
- OBJECTIVE: Hashimoto's thyroiditis (HT) was described many years ago, but the etiopathogenesis remains unclear. Mannose-binding lectin (MBL) initiates complement activation in the lectin pathway. We determined MBL levels in children with HT and the associations thereof with thyroid hormone and thyroid autoantibody levels. METHODS: Thirty-nine patients with HT and 41 controls were enrolled from the pediatric outpatient clinics. Subjects were grouped according to their thyroid functions: Euthyroid, marked hypothyroidism and clinical/subclinical hyperthyroidism. MBL levels were compared among these groups. Serum MBL levels of the subjects were determined using MBL Human ELISA kit. RESULTS: Serum MBL levels were studied in serum samples from the 80 subjects (48 (60.0%) females). MBL levels in HT and control groups were 50.787±34.718 and 50.593±44.28 ng/ml (p=0,983), respectively. In HT group, there was no significant difference in MBL levels between thyroid function groups (p=0.869). In addition, gender was not detected as a factor for serum MBL levels. Also we found negative correlation between WBC and serum MBL levels (r=-0.532; p=0.050). Otherwise there was no correlation between TSH, anti-TPO and anti-TG with serum MBL levels. CONCLUSION: MBL levels did not decrease in HT patients. Further research is needed to elucidate more fully any role for MBL in the development of autoimmune thyroid disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 21484902
- Volume :
- 10
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Northern Clinics of Istanbul
- Publication Type :
- Academic Journal
- Accession number :
- 164791534
- Full Text :
- https://doi.org/10.14744/nci.2022.22058