PRELIMINARY ASSESSMENT OF THE INFLUENCE OF CALCIUM ALGINATE BEADS ON THE DISSOLUTION OF MELOXICAM.

The purpose of the study was to evaluate the preparation of alginate-based microparticles with meloxicam (MLX). A poorly soluble substance classified as BCS class II was chosen as a model substance. Ionotropic gelation was the process used for the formation of microparticles. The impact of the carrier on the dissolution of MLX from this formulation was also investigated. The study was realized in a few steps: preparation of polymer particles containing suspended MLX in their structure; drying them in various conditions (room temperature, freeze-drying); morphology characterization, and then assessment of the impact of polymer on the dissolution of the model substance. Also, DDSolver software was used for checking the similarity of release profiles. The validated UV-Vis spectrophotometric method was used for MLX determination on different steps of work. As it showed, calcium alginate particles were successfully prepared with ionotropic gelation. The drying method of prepared particles has a substantial impact on the release profiles of meloxicam, and these formulations significantly improve the MLX release from this form of the delivery system [ABSTRACT FROM AUTHOR]