Back to Search
Start Over
Altered neurovascular coupling in patients with vascular cognitive impairment: a combined ASL-fMRI analysis.
- Source :
- Frontiers in Aging Neuroscience; 2023, p1-12, 12p
- Publication Year :
- 2023
-
Abstract
- Background and objective: This study aims to examine the role of neurovascular coupling (NVC) in vascular cognitive impairment (VCI) by investigating the relationship between white matter lesion (WML) burden, NVC, and cognitive deficits. Additionally, we aim to explore the potential of NVC as a tool for understanding the neural mechanisms underlying VCI. Methods: This study included thirty-eight small vessel disease cognitive impairment (SVCI) patients, 34 post-stroke cognitive impairment (PSCI) patients, and 43 healthy controls (HC). Comprehensive assessments, including neuroimaging and neuropsychological testing, were conducted to evaluate cognitive function. WML burden was measured and correlated with NVC coefficients to examine the relationship between white matter pathology and NVC. Mediation analysis was employed to explore the link relationship between NVC, WML burden, and cognitive function. Results: The present study showed that NVC was significantly reduced in the SVCI and PSCI groups compared with HCs at both whole-brain and brain region level. The analysis revealed notable findings regarding NVC in relation to WML burden and cognitive function in VCI patients. Specifically, reduced NVC coefficients were observed within higher order brain systems responsible for cognitive control and emotion regulation. Mediation analysis demonstrated that NVC played a mediating role in the relationship between WML burden and cognitive impairment. Conclusion: This study reveals the mediating role of NVC in the relationship between WML burden and cognitive function in VCI patients. The results demonstrate the potential of the NVC as an accurate measure of cognitive impairment and its ability to identify specific neural circuits affected by WML burden. [ABSTRACT FROM AUTHOR]
- Subjects :
- COGNITION disorder risk factors
CEREBRAL small vessel diseases
RESEARCH
DIGITAL image processing
STATISTICS
STROKE
CEREBRAL circulation
ONE-way analysis of variance
MAGNETIC resonance imaging
BRAIN mapping
MANN Whitney U Test
REGRESSION analysis
WHITE matter (Nerve tissue)
NEURAL conduction
RISK assessment
NEUROPSYCHOLOGICAL tests
PEARSON correlation (Statistics)
T-test (Statistics)
COMPARATIVE studies
FACTOR analysis
STROKE patients
DESCRIPTIVE statistics
CHI-squared test
STATISTICAL hypothesis testing
STATISTICAL correlation
COGNITIVE testing
DATA analysis software
DATA analysis
SOCIODEMOGRAPHIC factors
NEURORADIOLOGY
DISEASE risk factors
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 16634365
- Database :
- Complementary Index
- Journal :
- Frontiers in Aging Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 164745489
- Full Text :
- https://doi.org/10.3389/fnagi.2023.1224525