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Programmatic Effectiveness of a Pediatric Typhoid Conjugate Vaccine Campaign in Navi Mumbai, India.

Authors :
Hoffman, Seth A
LeBoa, Christopher
Date, Kashmira
Haldar, Pradeep
Harvey, Pauline
Shimpi, Rahul
An, Qian
Zhang, Chenhua
Jayaprasad, Niniya
Horng, Lily
Fagerli, Kirsten
Borhade, Priyanka
Daruwalla, Savita
Dharmapalan, Dhanya
Gavhane, Jeetendra
Joshi, Shrikrishna
Rai, Rajesh
Rathod, Varsha
Shetty, Keertana
Warrier, Divyalatha S
Source :
Clinical Infectious Diseases; Jul2023, Vol. 77 Issue 1, p138-144, 7p
Publication Year :
2023

Abstract

Background The World Health Organization recommends vaccines for prevention and control of typhoid fever, especially where antimicrobial-resistant typhoid circulates. In 2018, the Navi Mumbai Municipal Corporation (NMMC) implemented a typhoid conjugate vaccine (TCV) campaign. The campaign targeted all children aged 9 months through 14 years within NMMC boundaries (approximately 320 000 children) over 2 vaccination phases. The phase 1 campaign occurred from 14 July 2018 through 25 August 2018 (71% coverage, approximately 113 420 children). We evaluated the phase 1 campaign's programmatic effectiveness in reducing typhoid cases at the community level. Methods We established prospective, blood culture–based surveillance at 6 hospitals in Navi Mumbai and offered blood cultures to children who presented with fever ≥3 days. We used a cluster-randomized (by administrative boundary) test-negative design to estimate the effectiveness of the vaccination campaign on pediatric typhoid cases. We matched test-positive, culture-confirmed typhoid cases with up to 3 test-negative, culture-negative controls by age and date of blood culture and assessed community vaccine campaign phase as an exposure using conditional logistic regression. Results Between 1 September 2018 and 31 March 2021, we identified 81 typhoid cases and matched these with 238 controls. Cases were 0.44 times as likely to live in vaccine campaign communities (programmatic effectiveness, 56%; 95% confidence interval [CI], 25% to 74%; P =.002). Cases aged ≥5 years were 0.37 times as likely (95% CI,.19 to.70; P =.002) and cases during the first year of surveillance were 0.30 times as likely (95% CI,.14 to.64; P =.002) to live in vaccine campaign communities. Conclusions Our findings support the use of TCV mass vaccination campaigns as effective population-based tools to combat typhoid fever. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10584838
Volume :
77
Issue :
1
Database :
Complementary Index
Journal :
Clinical Infectious Diseases
Publication Type :
Academic Journal
Accession number :
164725654
Full Text :
https://doi.org/10.1093/cid/ciad132