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Effect of TB Treatment on Neutrophil-Derived Soluble Inflammatory Mediators in TB Patients with and without HIV Coinfection.

Authors :
Sitoe, Nádia
Chelene, Imelda
Ligeiro, Sofia
Castiano, Celso
Ahmed, Mohamed I. M.
Held, Kathrin
Nhassengo, Pedroso
Khosa, Celso
Matavele-Chissumba, Raquel
Hoelscher, Michael
Rachow, Andrea
Geldmacher, Christof
Source :
Pathogens; Jun2023, Vol. 12 Issue 6, p794, 15p
Publication Year :
2023

Abstract

The mycobacteriological analysis of sputum samples is the gold standard for tuberculosis diagnosis and treatment monitoring. However, sputum production can be challenging after the initiation of TB treatment. As a possible alternative, we therefore investigated the dynamics of neutrophil-derived soluble inflammatory mediators during TB treatment in relation to HIV ART status and the severity of lung impairment. Plasma samples of TB patients with (N = 47) and without HIV (N = 21) were analyzed at baseline, month 2, month 6 (end of TB treatment) and month 12. Plasma levels of MMP-1, MMP-8, MPO and S100A8 markedly decreased over the course of TB treatment and remained at similar levels thereafter. Post-TB treatment initiation, significantly elevated plasma levels of MMP-8 were detected in TB patients living with HIV, especially if they were not receiving ART treatment at baseline. Our data confirm that the plasma levels of neutrophil-based biomarkers can be used as candidate surrogate markers for TB treatment outcome and HIV-infection influenced MMP-8 and S100A8 levels. Future studies to validate our results and to understand the dynamics of neutrophils-based biomarkers post-TB treatment are needed. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20760817
Volume :
12
Issue :
6
Database :
Complementary Index
Journal :
Pathogens
Publication Type :
Academic Journal
Accession number :
164703100
Full Text :
https://doi.org/10.3390/pathogens12060794