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First Results of Concurrent Chemoradiation with Two Courses of 5 × 25 mg/m 2 Cisplatin for Locally Advanced Head and Neck Cancer.
- Source :
- Journal of Personalized Medicine; Jun2023, Vol. 13 Issue 6, p1006, 13p
- Publication Year :
- 2023
-
Abstract
- Many patients with squamous cell carcinoma of the head and neck (SCCHN) receive cisplatin-based chemoradiation. Cisplatin 100 mg/m<superscript>2</superscript> every three weeks is toxic and alternative cisplatin regimens are desired. Two courses of 20 mg/m<superscript>2</superscript>/day 1–5 (cumulative 200 mg/m<superscript>2</superscript>) were shown to be similarly effective and better tolerated than 100 mg/m<superscript>2</superscript> every three weeks. Previous studies suggested that cumulative doses >200 mg/m<superscript>2</superscript> may further improve outcomes. In this study, 10 patients (group A) receiving two courses of 25 mg/m<superscript>2</superscript>/day 1–5 (cumulative 250 mg/m<superscript>2</superscript>) in 2022 were retrospectively matched and compared to 98 patients (group B) receiving two courses of 20 mg/m<superscript>2</superscript>/day 1–5 or 25 mg/m<superscript>2</superscript>/day 1–4 (cumulative 200 mg/m<superscript>2</superscript>). Follow-up was limited to 12 months to avoid bias. Group A achieved non-significantly better 12-month loco-regional control (100% vs. 83%, p = 0.27) and metastases-free survival (100% vs. 88%, p = 0.38), and similar overall survival (89% vs. 88%, p = 0.90). No significant differences were found regarding toxicities, completion of chemotherapy, and interruption of radiotherapy. Given the limitations of this study, chemoradiation with two courses of 25 mg/m<superscript>2</superscript>/day 1–5 appears an option for carefully selected patients as a personalized treatment approach. Longer follow-up and a larger sample size are needed to properly define its role. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEAD & neck cancer
CHEMORADIOTHERAPY
SQUAMOUS cell carcinoma
Subjects
Details
- Language :
- English
- ISSN :
- 20754426
- Volume :
- 13
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Journal of Personalized Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 164685307
- Full Text :
- https://doi.org/10.3390/jpm13061006