Back to Search
Start Over
Clinical usefulness of splanchnic oxygenation in predicting necrotizing enterocolitis in extremely preterm infants: a cohort study.
- Source :
- BMC Pediatrics; 7/1/2023, Vol. 23 Issue 1, p1-8, 8p
- Publication Year :
- 2023
-
Abstract
- Background: Impaired intestinal microcirculation seems to play an important role in the pathogenesis of necrotizing enterocolitis (NEC). A previous study showed that a SrSO<subscript>2</subscript> < 30% is associated with an increased risk of developing of NEC. We aimed to determine the clinical usefulness of the cut off < 30% for SrSO<subscript>2</subscript> in predicting NEC in extremely preterm neonates. Methods: This is a combined cohort observational study. We added a second cohort from another university hospital to the previous cohort of extremely preterm infants. SrSO<subscript>2</subscript> was measured for 1–2 h at days 2–6 after birth. To determine clinical usefulness we assessed sensitivity, specificity, positive and negative predictive values for mean SrSO<subscript>2</subscript> < 30. Odds ratio to develop NEC was assessed with generalized linear model analysis, adjusting for center. Results: We included 86 extremely preterm infants, median gestational age 26.3 weeks (range 23.0-27.9). Seventeen infants developed NEC. A mean SrSO<subscript>2</subscript> < 30% was found in 70.5% of infants who developed NEC compared to 33.3% of those who did not (p = 0.01). Positive and negative predictive values were 0.33 CI (0.24–0.44) and 0.90 CI (0.83–0.96), respectively. The odds of developing NEC were 4.5 (95% CI 1.4–14.3) times higher in infants with SrSO2 < 30% compared to those with SrSO2 ≥ 30%. Conclusions: A mean SrSO<subscript>2</subscript> cut off ≥ 30% in extremely preterm infants between days 2–6 after birth may be useful in identifying infants who will not develop NEC. [ABSTRACT FROM AUTHOR]
- Subjects :
- PREMATURE infants
COHORT analysis
ENTEROCOLITIS
OXYGEN in the blood
NEWBORN infants
Subjects
Details
- Language :
- English
- ISSN :
- 14712431
- Volume :
- 23
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 164659225
- Full Text :
- https://doi.org/10.1186/s12887-023-04145-4