PINK1: From Parkinson's disease to mitophagy and back again.

The genetics of Parkinson's disease has been key to unravelling the PINK1-dependent mitophagy process. Here, we discuss the implications of a 2010 PLOS Biology paper that shed light on the functional importance of PINK1 in the mitophagy cascade. PINK1-dependent mitophagy is thought to be a factor in Parkinson's disease and is being investigated for therapeutic targeting. This Perspective looks back at a 2010 PLOS Biology paper that shed light on the functional importance of PINK1 in the mitophagy cascade. [ABSTRACT FROM AUTHOR]