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Gender differences in prevalence and associated factors of metabolic syndrome in first-treatment and drug-naïve schizophrenia patients.
- Source :
- Annals of General Psychiatry; 6/28/2023, Vol. 22 Issue 1, p1-10, 10p
- Publication Year :
- 2023
-
Abstract
- Background: Metabolic syndromes (MetS) are clinical syndromes involving multiple pathological states with distinct gender-specific clinical patterns. As a serious disorder associated with psychiatric conditions, the prevalence of MetS is significantly higher in the population with schizophrenia (Sch). The aim of this paper is to report gender differences in the prevalence, associated factors and severity-related factors of MetS in first-treatment and drug-naïve (FTDN) patients with Sch. Methods: A total of 668 patients with FTDN Sch were included in this study. We collected socio-demographic and general clinical information on the target population, measured and evaluated common metabolic parameters and routine biochemical indicators, and assessed the severity of psychiatric symptoms using Positive and Negative Symptom Scale (PANSS). Results: In the target group, the prevalence of MetS was significantly higher in women (13.44%, 57/424) than in men (6.56%, 16/244). In the males, waist circumference (WC), fasting blood glucose (FBG), diastolic blood pressure (DBP), and triglycerides (TG) were risk factors for MetS, while systolic blood pressure (SBP), TG, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and platelet (PLT) were risk factors for the females. More importantly, for the females, we found that age, LDL-C, PANSS scores and blood creatinine (CRE) were risk factors for higher MetS scores, while onset age and hemoglobin (HGB) were protective factors. Conclusion: There are significant gender differences in the prevalence of MetS and its factors among patients with FTDN Sch. The prevalence of MetS is higher and the factors that influence MetS are more numerous and extensive in females. The mechanisms of this difference need further research and clinical intervention strategies should be formulated with gender differences. [ABSTRACT FROM AUTHOR]
- Subjects :
- METABOLIC syndrome risk factors
TRIGLYCERIDES
LIPOPROTEINS
HDL cholesterol
HEMOGLOBINS
SCHIZOPHRENIA
CROSS-sectional method
SYSTOLIC blood pressure
BLOOD platelets
AGE distribution
BLOOD sugar
SEX distribution
SEVERITY of illness index
RISK assessment
COMPARATIVE studies
DIASTOLIC blood pressure
METABOLIC syndrome
DESCRIPTIVE statistics
WAIST circumference
AGE factors in disease
CREATININE
CHOLESTEROL
Subjects
Details
- Language :
- English
- ISSN :
- 1744859X
- Volume :
- 22
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Annals of General Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 164607929
- Full Text :
- https://doi.org/10.1186/s12991-023-00455-0