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The effect of agmatine administration on ischemic-reperfused isolated rat heart.
- Source :
- Journal of Cardiovascular Pharmacology & Therapeutics; Jan2001, Vol. 6 Issue 1, p37-45, 9p
- Publication Year :
- 2001
-
Abstract
- <bold>Background: </bold>The natural polyamine Agmatine (Ag) plays a significant role in protection of nerve cell ischemic injury. A previous report indicated that Ag given intraperitoneally to rats enhanced the recovery of the heart from ischemic injury. Based on this initial observation, a larger investigation was undertaken to explore a dose-response effect and possible mechanisms underlying the protective effects.<bold>Methods: </bold>Using the modified Langendorff model, 36 isolated hearts were divided into five groups: group 1, hearts receiving 100 microM/L Ag pre-ischemia (n=7); group 2, hearts receiving 100 microM/L Ag pre- and post-ischemia, (n=7); group 3, hearts receiving 250 microM/L Ag pre-ischemia (n=7); group 4, hearts receiving 250 microM/L Ag pre- and postischemia (n=7); and group 5, hearts receiving Krebs-Hensleit solution served as control (n=8). The study design included 20 minutes of perfusion, 30 minutes of global ischemia, and 30 minutes of reperfusion.<bold>Results: </bold>After ischemia, group 2 developed higher left ventricular pressure P(max) (P<0.01), improved first-derivative of the rise (dP/dt max; P<0.02), and fall (dP/dt min; P<0.04) in left ventricular pressure, and the area calculated under the left-ventricle developed pressure curve (pressure-time integral; P<0.015), but coronary flow was not significantly increased (P=0.06) compared to the control group. Group 1 had improved diastolic recovery: dP/dt min (P<0.05) and coronary flow (P<0.03), compared with the control group. Group 3 had improved P(max) (P<0.01), dP/dt min (P<0.01), and coronary flow (P<0.02); group 4 had no improvement in all hemodynamic parameters.<bold>Conclusion: </bold>Low doses of Ag given pre- and post-ischemia, and high doses given only pre-ischemia have favorable, protective effects on the hemodynamic recovery of isolated rat heart undergoing global ischemia and reperfusion. [ABSTRACT FROM AUTHOR]
- Subjects :
- ISCHEMIA
HEART abnormalities
REPERFUSION
NEURONS
BLOOD circulation disorders
REPERFUSION injury
CORONARY heart disease complications
ANIMAL experimentation
ANIMALS
CORONARY disease
DOSE-effect relationship in pharmacology
LEFT heart ventricle
HEART physiology
HEMODYNAMICS
MYOCARDIAL reperfusion complications
ORGANIC compounds
RATS
PARENTERAL infusions
PREVENTION
Subjects
Details
- Language :
- English
- ISSN :
- 10742484
- Volume :
- 6
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Cardiovascular Pharmacology & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 16460060
- Full Text :
- https://doi.org/10.1177/107424840100600105