اثر عصاره آبی كورم زعفران بر سطح گلوكز خون وآنزيمهاي كبدي موشهاي صحرايی ديابتی شده با استربتوزوتوسين.

The investigation of saffron's pharmacological properties and its active ingredients is crucial for understanding its potential clinical and health applications in humans. Diabetes, a chronic disease characterized by impaired insulin secretion or increased insulin resistance, has prompted the exploration of herbal remedies with fewer side effects compared to chemical medications. This study aimed to examine the effects of an aqueous extract of saffron corm on blood glucose levels and liver enzymes in diabetic rats. Male rats were divided into healthy and diabetic groups, with and without treatment, and administered doses of 100, 200, and 300 mg.kg^-1 of the saffron corm extract. Diabetes was induced using streptozotocin. The mortality rate significantly decreased after the administration of the saffron corm extract. Doses of 200 and 300 mg.kg^-1 effectively controlled weight loss in diabetic rats, with the 300 mg.kg^-1 dose being comparable to the control group without diabetes. The results demonstrated a significant reduction in fasting blood glucose levels following the administration of the saffron corm extract. Specifically, the 300 mg.kg^-1 dose on the 15th day after diabetes induction led to a significant decrease in blood glucose levels. This hypoglycemic effect may be attributed to increased insulin secretion from pancreatic beta cells. Furthermore, the 300 mg.kg^-1 dose resulted in a decrease in the hepatic enzymes AST and ALT in the blood serum. These findings indicate that the aqueous extract of saffron corm not only reduces blood sugar and aids in diabetes management but also regulates liver enzyme activity. [ABSTRACT FROM AUTHOR]