The relevance of antioxidants, oxidative stress and inflammatory parameters in rheumatoid arthritis patients.

The current study has investigated the relationship between the inflammatory status, oxidative stress and antioxidant parameters of persons with rheumatoid arthritis (RA). Material and Methods: All subjects' patients, and healthy controls, followed by estimation levels of adiponectin (ADP), protein carbonyls (PC), Malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT). And show the differences of concentration in all participants. Finally, investigate the Pearson's correlation (r) between these parameters. Results: there were increased significant variations in comparison between patients and healthy group in ADP, MDA, PC (P<0.01), whereas CAT, SOD (P<0.01), was remarkable lower in RA persons as compared to the healthy control. There was positive significant correlation between ADP with PC (r=0.27), and CAT (r=0.34). While moderate positive correlation was found between ADP with SOD (r=0.19). A negative correlation was observed with MDA (r= -0.04). The association of MDA with the other studied parameters showed a positive relationship between MDA with PC (r=0.12), while a negative correlation was found with SOD (r=-0.15). Conclusion: there were increased in the levels of oxidative stress in persons affected by RA demonstrated by elevated serum MDA, and PC that have resulted to alterations in the concentrations of some antioxidants, such as CAT, and SOD. In addition, there was an increasing in concentration of ADP. Regarding to the correlation there is positively correlated between ADP with PC, SOD, and CAT. MDA and PC have a significant positive association. [ABSTRACT FROM AUTHOR]