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Antioxidant, antimicrobial, and cytotoxic potential of Euphorbia royleana extract-mediated silver and copper oxide nanoparticles.
- Source :
- Chemical Papers; Aug2023, Vol. 77 Issue 8, p4643-4657, 15p
- Publication Year :
- 2023
-
Abstract
- The present research demonstrates the first-time successful synthesis of silver nanoparticles (Ag NPs) and copper oxide nanoparticles (Cu<subscript>2</subscript>O NPs) from Euphorbia royleana pulp extract. The morphological features of synthesized NPs were examined using XRD, FTIR, FE-SEM, and TEM. With the presence of surface-bonded phenolic groups, the particle size of Ag NPs and Cu<subscript>2</subscript>O NPs (spherical) was revealed to be 20.53 ± 1.15 nm and 3.06 ± 0.04 nm, respectively. The DPPH and FRAP assays demonstrated significant antioxidant activity (Ag NPs: 60.44 µg/mL and 141.86 µg/mL; Cu<subscript>2</subscript>O NPs: 63.55 µg/mL and 138.9 µg/mL, respectively). Additionally, Ag and Cu<subscript>2</subscript>O NPs showed good antimicrobial activity (31.25 to 500 µg/mL) against Bacillus subtilis,Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Fusarium oxysporum, and Rosellinia necatrix. Against colon cancer cell lines, nanoparticles showed potent cytotoxic activity (IC<subscript>50</subscript>-50.12 µg/mL for Ag NPs and 61.93 µg/mL for Cu<subscript>2</subscript>O NPs). As a result of their significant biological activities, the synthesized NPs showed potency to be utilized in various biomedical applications after in vivo studies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03666352
- Volume :
- 77
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Chemical Papers
- Publication Type :
- Academic Journal
- Accession number :
- 164433104
- Full Text :
- https://doi.org/10.1007/s11696-023-02814-3