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Differences in genetic risk score profiles for drug use disorder, major depression, and ADHD as a function of sex, age at onset, recurrence, mode of ascertainment, and treatment.
- Source :
- Psychological Medicine; Jun2023, Vol. 53 Issue 8, p3448-3460, 13p
- Publication Year :
- 2023
-
Abstract
- Background: Do genetic risk profiles for drug use disorder (DUD), major depression (MD), and attention-deficit hyperactivity disorder (ADHD) differ substantially as a function of sex, age at onset (AAO), recurrence, mode of ascertainment, and treatment? Methods: Family genetic risk scores (FGRS) for MD, anxiety disorders, bipolar disorder, schizophrenia, alcohol use disorder, DUD, ADHD, and autism-spectrum disorder were calculated from 1st–5th degree relatives in the Swedish population born 1932–1995 (n = 5 829 952). Profiles of these FGRS were obtained and compared across various subgroups of DUD, MD, and ADHD cases. Results: Differences in FGRS profiles for DUD, MD, and ADHD by sex were modest, but they varied substantially by AAO, recurrence, ascertainment, and treatment with scores typically higher in cases with greater severity (e.g. early AAO, high recurrence, ascertainment in high intensity clinical settings, and treatment). However, severity was not always related to purer genetic profiles, as genetic risk for many disorders often increased together. However, some results, such as by mode of ascertainment from different Swedish registries, produced qualitative differences in FGRS profiles. Conclusions: Differences in FGRS profiles for DUD, MD, and ADHD varied substantially by AAO, recurrence, ascertainment, and treatment. Replication of psychiatric studies, particularly those examining genetic factors, may be difficult unless cases are matched not only by diagnosis but by important clinical characteristics. Genetic correlations between psychiatric disorders could arise through one disorder impacting on the patterns of ascertainment for the other, rather than from the direct effects of shared genetic liabilities. [ABSTRACT FROM AUTHOR]
- Subjects :
- GENETIC risk score
SUBSTANCE abuse treatment
MENTAL depression genetics
TREATMENT of attention-deficit hyperactivity disorder
SUBSTANCE abuse
AGE distribution
GENETIC testing
RISK assessment
ATTENTION-deficit hyperactivity disorder
SEX distribution
DISEASE relapse
COMPARATIVE studies
AGE factors in disease
MENTAL depression
RESEARCH funding
Subjects
Details
- Language :
- English
- ISSN :
- 00332917
- Volume :
- 53
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Psychological Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 164382878
- Full Text :
- https://doi.org/10.1017/S0033291721005535