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Humoral immune responses remain quantitatively impaired but improve qualitatively in anti-CD20-treated patients with multiple sclerosis after three or four COVID-19 vaccinations.
- Source :
- Multiple Sclerosis Journal; Jun2023, Vol. 29 Issue 7, p884-888, 5p
- Publication Year :
- 2023
-
Abstract
- Objective: To analyze anti-SARS-CoV-2-S1-IgG levels, avidity, Omicron BA.2 variant neutralizing capacity, and SARS-CoV-2-specific T cells in anti-CD20-treated patients with multiple sclerosis (aCD20pwMS) after two, three, or four COVID-19 vaccinations. Results: Frequencies of aCD20pwMS with detectable SARS-CoV-2-S1-IgG increased moderately between two (31/61 (51%)), three (31/57 (54%)), and four (17/26 (65%)) vaccinations. However, among patients with detectable SARS-CoV-2-S1-IgG, frequencies of high avidity (6/31 (19%) vs 11/17 (65%)) and Omicron neutralizing antibodies (0/10 (0%) vs 6/10 (60%)) increased strongly between two and four vaccinations. SARS-CoV-2-specific T cells were detectable in >92% after two or more vaccinations Conclusion: Additional vaccinations qualitatively improve SARS-CoV-2 antibody responses. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13524585
- Volume :
- 29
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Multiple Sclerosis Journal
- Publication Type :
- Academic Journal
- Accession number :
- 164374998
- Full Text :
- https://doi.org/10.1177/13524585231161253