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A single case report of STN-DBS for severe crack-cocaine dependence: double-blind ON vs. SHAM randomized controlled assessment.
- Source :
- Frontiers in Psychiatry; 2023, p01-06, 6p
- Publication Year :
- 2023
-
Abstract
- Crack-cocaine dependence is a severe condition with a high mortality rate. This single case study report details the first deep brain stimulation (DBS) trial targeting the sub-thalamic nucleus (STN) for crack-cocaine dependence. The investigation aimed to assess the e ects of STN-DBS on cocaine craving and cocaine use, as well as STN-DBS safety and tolerance in this indication. In this pilot study, we performed double blind cross-over trials, with "ON-DBS" vs. "SHAM-DBS" for 1-month periods. STN-DBS failed to reduce cocaine craving and use. An episode of DBS-induced hypomania occurred after several weeks of cocaine intake at stimulation parameters previously well tolerated. Future research on cocaine dependence should be conducted after a prolonged abstinence period and/or explore novel types of stimulation patterns. [ABSTRACT FROM AUTHOR]
- Subjects :
- COCAINE-induced disorders
DEEP brain stimulation
CROSSOVER trials
Subjects
Details
- Language :
- English
- ISSN :
- 16640640
- Database :
- Complementary Index
- Journal :
- Frontiers in Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 164329767
- Full Text :
- https://doi.org/10.3389/fpsyt.2023.1146492