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Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment.

Authors :
Rajeev, Vismitha
Chai, Yuek Ling
Poh, Luting
Selvaraji, Sharmelee
Fann, David Y.
Jo, Dong-Gyu
De Silva, T. Michael
Drummond, Grant R.
Sobey, Christopher G.
Arumugam, Thiruma V.
Chen, Christopher P.
Lai, Mitchell K. P.
Source :
Acta Neuropathologica Communications; 6/12/2023, Vol. 11 Issue 1, p1-23, 23p
Publication Year :
2023

Abstract

Vascular cognitive impairment (VCI) describes a wide spectrum of cognitive deficits related to cerebrovascular diseases. Although the loss of blood flow to cortical regions critically involved in cognitive processes must feature as the main driver of VCI, the underlying mechanisms and interactions with related disease processes remain to be fully elucidated. Recent clinical studies of cerebral blood flow measurements have supported the role of chronic cerebral hypoperfusion (CCH) as a major driver of the vascular pathology and clinical manifestations of VCI. Here we review the pathophysiological mechanisms as well as neuropathological changes of CCH. Potential interventional strategies for VCI are also reviewed. A deeper understanding of how CCH can lead to accumulation of VCI-associated pathology could potentially pave the way for early detection and development of disease-modifying therapies, thus allowing preventive interventions instead of symptomatic treatments. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20515960
Volume :
11
Issue :
1
Database :
Complementary Index
Journal :
Acta Neuropathologica Communications
Publication Type :
Academic Journal
Accession number :
164263071
Full Text :
https://doi.org/10.1186/s40478-023-01590-1