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Research on in-situ detection of double-ended clamped beam biosensors.

Authors :
Wang, Jingjing
Xu, Baozheng
Shi, Libo
Cao, Houyong
Zhu, Longyang
Wei, Xi
Source :
Ferroelectrics; 2023, Vol. 608 Issue 1, p41-51, 11p
Publication Year :
2023

Abstract

One of the most frequent malignant tumors seen in clinics is primary liver cancer, also referred to as the "king of cancers." Therefore, the necessity for an effective and precise detection technique is urgent. Compared with the cantilever beam, the double-ended clamped beam has the characteristics of higher resonance frequency and stronger noise immunity, so it has a good application prospect as a biosensor. This paper takes the double-ended clamped beam biosensor as the object and focuses on the method that can be applied to the early diagnosis and detection of liver cancer. The manufacturing process of the double-ended clamped beam and the biofunctional modification of the beam surface were introduced. Meantime, this paper introduces the integration of the composite double-ended clamped beam biosensor system. As a result, a high-sensitivity, high-reliability in situ real-time monitoring technology for early-stage liver cancer is proposed. A composite double-ended clamped beam made of silicon and silicon nitride is used. The size of the double-ended clamped beam is 280 µm × 50µm × 5µm. This paper provides a low-cost, portable, and rapid early diagnosis method for liver cancer, which has very significant application value in the field of early cancer screening. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00150193
Volume :
608
Issue :
1
Database :
Complementary Index
Journal :
Ferroelectrics
Publication Type :
Academic Journal
Accession number :
164242935
Full Text :
https://doi.org/10.1080/00150193.2023.2198442