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Phase 2 KEYNOTE‐B68 study: pembrolizumab every 6 weeks in relapsed/refractory (R/R) classical Hodgkin lymphoma (cHL) or primary mediastinal B‐cell lymphoma (PMBCL).

Authors :
McDonald, A.
Verburgh, E.
Gotti, M.
Pinto, A.
Zaucha, J.
Ivanov, V.
Melnichenko, V.
Mocikova, H.
Ozcan, M.
Patti, C.
Farias, J.
Goncalves, I.
Kuchkova, O.
Mayer, J.
Saydam, G.
Tomassetti, S.
Pathiraja, K.
Ryland, K.
Chakraborty, S.
Jurczak, W.
Source :
Hematological Oncology; Jun2023 Supplement 1, Vol. 41, p575-577, 3p
Publication Year :
2023

Abstract

B Conclusions: b With approximately 9 mo of follow-up, pembro 400 mg Q6W had robust antitumor activity in pts with R/R cHL and R/R PMBCL, with ORR similar to that with pembro 200 mg Q3W. B Introduction: b Pembrolizumab (pembro) was originally approved by the FDA for the treatment of R/R cHL and R/R PMBCL at 200 mg every 3 weeks (Q3W). Treatment-related AEs occurred in 24 pts (40%) with R/R cHL and 2 (33.3%) with R/R PMBCL; grade >=3 treatment-related AEs occurred in 3 pts (5%) and 1 pt (16.7%), respectively. [Extracted from the article]

Details

Language :
English
ISSN :
02780232
Volume :
41
Database :
Complementary Index
Journal :
Hematological Oncology
Publication Type :
Academic Journal
Accession number :
164231255
Full Text :
https://doi.org/10.1002/hon.3164_431