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Reply to "Efficacy of unithiol (2,3-dimercaptopropanesulfonate) and acetylcysteine in a patient with arthroplastic cobalt toxicity".
- Source :
- Clinical Toxicology (15563650); May2023, Vol. 61 Issue 5, p412-413, 2p
- Publication Year :
- 2023
-
Abstract
- Dear Editor, We read with great interest the letter from Pelclova and Lach [[1]] on the efficacy of unithiol (2,3-dimercaptopropanesulfonate) and acetylcysteine in a patient with arthroplastic cobalt toxicity. Acetylcysteine increases cobalt urinary excretion and consistently maintains the serum cobalt concentration less than the threshold of 10 g/L, which we believe to be the goal in patients with metal-on-metal implants in order to minimise cobalt toxicity from the existing prosthesis [[3]]. The authors stated that chelation therapy, either with unithiol or acetylcysteine, is often clinically inefficient in patients with very elevated cobalt concentrations (greater than 100 g/L) as long as the damaged prosthesis remains I in situ i . [Extracted from the article]
- Subjects :
- COBALT
ACETYLCYSTEINE
ARTIFICIAL hip joints
CHELATION therapy
TOTAL hip replacement
Subjects
Details
- Language :
- English
- ISSN :
- 15563650
- Volume :
- 61
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Clinical Toxicology (15563650)
- Publication Type :
- Academic Journal
- Accession number :
- 164224876
- Full Text :
- https://doi.org/10.1080/15563650.2023.2205007