Site-specific fabrication of a melanin-like pigment through spatially confined progressive assembly on an initiator-loaded template.

Melanin-like nanomaterials have emerged in surface biofunctionalization in a material-independent manner due to their versatile adhesion arising from their catechol-rich structures. However, the unique adhesive properties of these materials ironically raise difficulties in their site-specific fabrication. Here, we report a method for site-specific fabrication and patterning of melanin-like pigments, using progressive assembly on an initiator-loaded template (PAINT), different from conventional lithographical methods. In this method, the local progressive assembly could be naturally induced on the given surface pretreated with initiators mediating oxidation of the catecholic precursor, as the intermediates generated from the precursors during the progressive assembly possess sufficient intrinsic underwater adhesion for localization without diffusion into solution. The pigment fabricated by PAINT showed efficient NIR-to-heat conversion properties, which can be useful in biomedical applications such as the disinfection of medical devices and cancer therapies. Melanin-like materials are becoming important for surface biofunctionalization due to versatile adhesion, but are challenging to prepare in a site-specific manner. Here, the authors report a method using progressive assembly on a catalytic template, for site-specific fabrication and patterning of melanin-like pigments. [ABSTRACT FROM AUTHOR]