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Prevalence and Clinical Outcomes of Respiratory Syncytial Virus vs Influenza in Adults Hospitalized With Acute Respiratory Illness From a Prospective Multicenter Study.
- Source :
- Clinical Infectious Diseases; Jun2023, Vol. 76 Issue 11, p1980-1988, 9p
- Publication Year :
- 2023
-
Abstract
- Background Current understanding of severe respiratory syncytial virus (RSV) infections in adults is limited by clinical underrecognition. We compared the prevalence, clinical characteristics, and outcomes of RSV infections vs influenza in adults hospitalized with acute respiratory illnesses (ARIs) in a prospective national surveillance network. Methods Hospitalized adults who met a standardized ARI case definition were prospectively enrolled across 3 respiratory seasons from hospitals participating across all sites of the US Hospitalized Adult Influenza Vaccine Effectiveness Network (2016–2019). All participants were tested for RSV and influenza using real-time reverse-transcription polymerase chain reaction assay. Multivariable logistic regression was used to test associations between laboratory-confirmed infection and characteristics and clinical outcomes. Results Among 10 311 hospitalized adults, 6% tested positive for RSV (n = 622), 18.8% for influenza (n = 1940), and 75.1% negative for RSV and influenza (n = 7749). Congestive heart failure (CHF) or chronic obstructive pulmonary disease (COPD) was more frequent with RSV than influenza (CHF: 37.3% vs 28.8%, P <.0001; COPD: 47.6% vs 35.8%, P <.0001). Patients with RSV more frequently had longer admissions (odds ratio [OR], 1.38; 95% confidence interval [CI], 1.06–1.80) for stays >1 week) and mechanical ventilation (OR, 1.45; 95% CI, 1.09–1.93) compared with influenza but not compared with the influenza-negative group (OR, 1.03; 95% CI,.82–1.28 and OR, 1.17; 95% CI,.91–1.49, respectively). Conclusions The prevalence of RSV across 3 seasons was considerable. Our findings suggest that those with RSV have worse outcomes compared with influenza and frequently have cardiopulmonary conditions. This study informs future vaccination strategies and underscores a need for RSV surveillance among adults with severe ARI. [ABSTRACT FROM AUTHOR]
- Subjects :
- INFLUENZA diagnosis
INFLUENZA epidemiology
RESEARCH
HOSPITALS
CLINICAL pathology
CONFIDENCE intervals
MULTIVARIATE analysis
RESPIRATORY infections
HEALTH outcome assessment
PATIENTS
SEASONS
BUSINESS networks
HOSPITAL admission & discharge
ARTIFICIAL respiration
HOSPITAL care
SYMPTOMS
INFLUENZA
DESCRIPTIVE statistics
RESEARCH funding
RESPIRATORY syncytial virus infections
POLYMERASE chain reaction
LOGISTIC regression analysis
ODDS ratio
ACUTE diseases
LONGITUDINAL method
COMORBIDITY
Subjects
Details
- Language :
- English
- ISSN :
- 10584838
- Volume :
- 76
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Clinical Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 164219235
- Full Text :
- https://doi.org/10.1093/cid/ciad031