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The effect of silicon groups on the physicochemical property and bioactivity of L‐phenylalanine derived poly(amide‐imide).
- Source :
- Journal of Biomedical Materials Research, Part B: Applied Biomaterials; Aug2023, Vol. 111 Issue 8, p1581-1593, 13p
- Publication Year :
- 2023
-
Abstract
- Poly(amide‐imide) (PAI), serving as a synthetic polymer, has been widely used in industry for excellent mechanical properties, chemical resistance and high thermal stability. However, lack of suitable cell niche and biological activity limited the further application of PAI in biomedical engineering. Herein, silicon modified L‐phenylalanine derived poly(amide‐imide) (PAIS) was synthesized by introducing silica to L‐phenylalanine derived PAI to improve physicochemical and biological performances. The influence of silicon amount on physicochemical, immune, and angiogenic performances of PAIS were systemically studied. The results show that PAIS exerts excellent hydrophilic, mechanical, biological activity. PAIS shows no effects on the number of macrophages, but can regulate macrophage polarization and angiogenesis in a dose‐dependent manner. This study advanced our understanding of silicon modification in PAI can modulate cell responses via initiating silicon concentration regulation. The acquired knowledge will provide a new strategy to design and optimize biomedical PAI in the future. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15524973
- Volume :
- 111
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Journal of Biomedical Materials Research, Part B: Applied Biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 164136731
- Full Text :
- https://doi.org/10.1002/jbm.b.35257