Mycobacterium Avium Complex Infection of the Spine in a Patient Without Acquired Immune Deficiency Syndrome: A Case Report and Literature Review.

But in this case, MAC infection with destructive changes of T SB 10-12 sb and L SB 4-5 sb in a middle-aged man with normal immune function was first reported and this also revealed the possibility of multiple abscesses in MAC infection. Keywords: Case Report; Metagenomic Next Generation Sequencing; Mycobacterium Avium Complex; Spinal Infection; Spine EN Case Report Metagenomic Next Generation Sequencing Mycobacterium Avium Complex Spinal Infection Spine 1707 1715 9 06/06/23 20230601 NES 230601 A 52-year-old patient misdiagnosed with spinal tuberculosis was successfully diagnosed with Mycobacterium avium infection using metagenomic next-generation sequencing and cured with four-drug combination protocol chemotherapy (amikacin, rifampicin, clarithromycin, ethambutol) and spinal fixation. In fact, the successful treatment of this patient confirms that the guidelines for pulmonary MAC infections are instructive for spinal infections and the four-drug combination protocol can be referenced. To date, MAC infection of the spine is rare, with only 17 cases reported in the English literature.[4] The diagnosis was confirmed by biopsy and microbial culture in 16 patients, while MAC infection was determined by PCR in only one patient (Table 2). [Extracted from the article]