Can the apparent transverse relaxation rate (R2*) evaluate the efficacy of concurrent chemoradiotherapy in locally advanced nasopharyngeal carcinoma? a preliminary experience.

Background: The use of the apparent transverse relaxation rate (R2^*) in nasopharyngeal carcinoma (NPC) has not been previously reported in the literature. The aim of this study was to investigate the role of the R2^* value in evaluating response to concurrent chemoradiotherapy (CCRT) in patients with NPC. Methods: Forty-one patients with locoregionally advanced NPC confirmed by pathology were examined by blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) before and after CCRT, and conventional MRI was performed 3 months after the completion of CCRT. All patients were divided into a responding group (RG) and a nonresponding group (NRG), according to MRI findings 3 months after the end of treatment. The R2^* values before (R2*_preT) and after (R2^*_postT) CCRT and the ΔR2^* (ΔR2^*=R2^*_postT – R2^*_preT) were calculated in the tumor. Results: Among the 41 patients, 26 were in the RG and 15 were in the NRG. There was no statistical difference in the R2^*_preT between RG and NRG (P = 0.307); however, there were significant differences in R2^*_postT and ΔR2^* (P < 0.001). The area under the curve of R2^*_postT and ΔR2^* for predicting the therapeutic response of NPC was 0.897 and 0.954, respectively, with cutoff values of 40.95 and 5.50 Hz, respectively. Conclusion: The R2^* value can be used as a potential imaging indicator to evaluate the therapeutic response of locoregionally advanced NPC. [ABSTRACT FROM AUTHOR]