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Kuwanon X from mulberry leaves exhibits antiviral activity against human adenoviruses.
- Source :
- Future Virology; Apr2023, Vol. 18 Issue 5, p279-288, 10p
- Publication Year :
- 2023
-
Abstract
- Aim: This study aimed to investigate the anti-adenoviral activity of stilbene derivatives from mulberry leaves. Materials & methods: The anti-adenoviral activity was tested against adenoviruses -3 and -7 on human airway epithelial cell models. Cytotoxicity was assessed by LDH assay. Adenoviral DNA was quantified by qPCR. Results: All five tested stilbene derivatives from mulberry leaves exhibited anti-adenoviral activity, with Kuwanon X showing the highest inhibitory effect. Kuwanon X showed no apparent cytotoxicity for a wide range of concentrations. The mechanistic study revealed that Kuwanon X did not affect viral entry and nuclear translocation of the adenoviral genome but reduced viral DNA production. Conclusion: Stilbene derivatives like Kuwanon X from mulberry leaves are good candidates for antiviral treatment against AdV. Compound from mulberry leaves shows highly inhibitory effect against human AdV. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17460794
- Volume :
- 18
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Future Virology
- Publication Type :
- Academic Journal
- Accession number :
- 163990869
- Full Text :
- https://doi.org/10.2217/fvl-2023-0001