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Rhodium(I)-catalyzed N-arylation of arylazocarboxylates: facile access to unsymmetrical N,N-diarylhydrazides.
- Source :
- New Journal of Chemistry; 6/7/2023, Vol. 47 Issue 21, p10147-10152, 6p
- Publication Year :
- 2023
-
Abstract
- A simple, efficient, and broad-scope rhodium(I)-catalyzed direct N-arylation of arylazocarboxylates with arylboronic acids has been developed, allowing access to a diverse range of unsymmetrical N,N-diarylhydrazides from readily available starting materials in high yields under extraordinary mild conditions. The reaction features easy operation, ambient temperature and low catalyst loading (as low as 0.1 mol%), as well as broad functional-group compatibility. The resulting N,N-diarylhydrazides could serve as versatile building blocks to furnish other structurally important or pharmaceutically interesting molecules. This protocol provides an attractive and complementary approach for the assembly of valuable N,N-diarylamine scaffolds. [ABSTRACT FROM AUTHOR]
- Subjects :
- ARYLATION
RHODIUM
LOW temperatures
Subjects
Details
- Language :
- English
- ISSN :
- 11440546
- Volume :
- 47
- Issue :
- 21
- Database :
- Complementary Index
- Journal :
- New Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 163983756
- Full Text :
- https://doi.org/10.1039/d3nj01022h