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Seroconversion of a Swine Herd in a Free-Range Rural Multi-Species Farm against HPAI H5N1 2.3.4.4b Clade Virus.

Authors :
Rosone, Francesca
Bonfante, Francesco
Sala, Marcello Giovanni
Maniero, Silvia
Cersini, Antonella
Ricci, Ida
Garofalo, Luisa
Caciolo, Daniela
Denisi, Antonella
Napolitan, Alessandra
Parente, Monja
Zecchin, Bianca
Terregino, Calogero
Scicluna, Maria Teresa
Source :
Microorganisms; May2023, Vol. 11 Issue 5, p1162, 12p
Publication Year :
2023

Abstract

Starting from October 2021, several outbreaks of highly pathogenic avian influenza virus (HPAIV) subtype H5N1 were reported in wild and domestic birds in Italy. Following the detection of an HPAIV in a free-ranging poultry farm in Ostia, province of Rome, despite the lack of clinical signs, additional virological and serological analyses were conducted on samples collected from free-ranging pigs, reared in the same holding, due to their direct contact with the infected poultry. While the swine nasal swabs were all RT-PCR negative for the influenza type A matrix (M) gene, the majority (%) of the tested pigs resulted serologically positive for the hemagglutination inhibition test and microneutralization assay, using an H5N1 strain considered to be homologous to the virus detected in the farm. These results provide further evidence of the worrisome replicative fitness that HPAI H5Nx viruses of the 2.3.4.4b clade have in mammalian species. Moreover, our report calls for additional active surveillance, to promptly intercept occasional spillover transmissions to domestic mammals in close contact with HPAI affected birds. Strengthened biosecurity measures and efficient separation should be prioritized in mixed-species farms in areas at risk of HPAI introduction. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20762607
Volume :
11
Issue :
5
Database :
Complementary Index
Journal :
Microorganisms
Publication Type :
Academic Journal
Accession number :
163970259
Full Text :
https://doi.org/10.3390/microorganisms11051162