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Effects of antioxidant supplementation on bone mineral density, bone mineral content and bone structure in healthy men during 60 days of 6° head‐down tilt bed rest: Results from a randomised controlled trial.
- Source :
- Nutrition Bulletin; Jun2023, Vol. 48 Issue 2, p256-266, 11p, 4 Charts
- Publication Year :
- 2023
-
Abstract
- Dietary countermeasures to mitigate detrimental spaceflight‐induced effects on bone health would alleviate the requirements and the consequences imposed by other types of countermeasures for this risk. We hypothesised that antioxidant supplementation during 60 days of 6° head‐down tilt bed rest (HDBR), an analogue of spaceflight, would have a protective effect on bone mineral density (BMD), content (BMC) and bone structure parameters. An exploratory, randomised, controlled, single‐blind intervention trial was conducted in a parallel design with 20 healthy male volunteers (age 34 ± 8 y, weight 74 ± 6 kg). The study included 14 days of baseline data collection (BDC) before bed rest, followed by 60 days of HDBR and a 14‐day recovery period. Ten subjects in the antioxidant group received a supplement (741 mg/d polyphenols, 2.1 g/d omega‐3 fatty acids, 168 mg/d vitamin E and 80 μg/d selenium) daily. Ten subjects in the control group received no supplement. The diet was consistent with dietary reference intakes, individually tailored based on the subject's bodyweight and strictly controlled. We measured whole‐body, lumbar spine and femur BMD and BMC, as well as BMD of the cortical and trabecular compartments of the distal radius and tibia, and cortical and trabecular thickness during BDC, HDBR and recovery. Data were analysed using linear mixed models. The supplementation of an antioxidant cocktail did not mitigate the deteriorating effects of HDBR on BMD, BMC and bone structure parameters. Our findings do not support a recommendation for antioxidant supplementation for astronauts. [ABSTRACT FROM AUTHOR]
- Subjects :
- THERAPEUTIC use of antioxidants
AEROBIC capacity
BONES
POLYPHENOLS
BODY weight
HEAD-down tilt position
BED rest
VITAMIN E
CONVALESCENCE
DIET
DIETARY supplements
RANDOMIZED controlled trials
PHYSICAL activity
PRE-tests & post-tests
T-test (Statistics)
COMPARATIVE studies
RESEARCH funding
BLIND experiment
OMEGA-3 fatty acids
QUESTIONNAIRES
DESCRIPTIVE statistics
BONE density
STATISTICAL sampling
BODY mass index
COMPUTED tomography
DATA analysis software
SPACE flight
SELENIUM
Subjects
Details
- Language :
- English
- ISSN :
- 14719827
- Volume :
- 48
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Nutrition Bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 163949369
- Full Text :
- https://doi.org/10.1111/nbu.12619