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Vascular Normalization Caused by Short-Term Lenvatinib Could Enhance Transarterial Chemoembolization in Hepatocellular Carcinoma.
- Source :
- Current Oncology; May2023, Vol. 30 Issue 5, p4779-4786, 8p, 2 Color Photographs, 2 Black and White Photographs
- Publication Year :
- 2023
-
Abstract
- We describe the clinical effects of short-term lenvatinib administration prior to conventional transarterial chemoembolization (cTACE) on tumor vasculature. Two patients with unresectable hepatocellular carcinoma underwent high-resolution digital subtraction angiography (DSA) and perfusion four-dimensional computed tomography during hepatic arteriography (4D-CTHA) before and after administration of lenvatinib treatment. The doses and periods of lenvatinib administration were, respectively, 12 mg/day for 7 days and 8 mg/day for 4 days. In both cases, high-resolution DSA revealed a decrease in dilatation and tortuosity of the tumor vessels. Furthermore, the tumor staining became more refined, and newly formed tiny tumor vessels were observed. Perfusion 4D-CTHA revealed a decrease in arterial blood flow to the tumor by 28.6% (from 487.9 to 139.5 mL/min/100 mg) and 42.5% (from 288.2 to 122.6 mL/min/100 mg) in the two cases, respectively. The cTACE procedure resulted in good lipiodol accumulation and complete response. Patients have remained recurrence-free for 12 and 11 months after the cTACE procedure, respectively. The administration of short-term lenvatinib in these two cases resulted in the normalization of tumor vessels, which likely led to improved lipiodol accumulation and a favorable antitumor effect. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHEMOEMBOLIZATION
DIGITAL subtraction angiography
BLOOD flow
COMPUTED tomography
Subjects
Details
- Language :
- English
- ISSN :
- 11980052
- Volume :
- 30
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Current Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 163940448
- Full Text :
- https://doi.org/10.3390/curroncol30050360