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Association between lipid metabolism and periodontitis in obese patients: a cross-sectional study.
- Source :
- BMC Endocrine Disorders; 5/25/2023, Vol. 23 Issue 1, p1-10, 10p
- Publication Year :
- 2023
-
Abstract
- Background: To investigate the association between clinical periodontal parameters of periodontitis, serum lipid metabolism markers and adipokines' levels in patients with obesity and periodontitis. Methods: A total of 112 patients admitted to Hospital of Xi'an Jiaotong University were included in this study. They were divided into normal body weight group (18.5 < body mass index, BMI < 25, n = 36), overweight group (25 ≤ BMI < 30, n = 38), and obesity group (BMI ≥ 30, n = 38) accordingly. The diagnosis of periodontitis was based on the newest international classification of periodontitis. Full-mouth clinical periodontal measurements included: plaque index, periodontal pocket depth, clinical attachment level, and bleeding on probing. Gingival crevicular fluid samples were analyzed for: Interleukin-1β, tumor necrosis factor-α, Interleukin-6 and C-reactive protein. Serum triglycerides, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol and glycosylated hemoglobin levels were measured. Visfatin, leptin, resistin, and adiponectin levels in serum were also measured. Results: The ratio of participants without periodontitis was significantly highest in normal weight group, and the proportion of severe periodontitis (stage III and IV) was highest in obesity group. The periodontal pocket depth, clinical attachment level, and the inflammatory cytokines in gingival crevicular fluid in obesity group and overweight group were higher than those in normal body weight group. The BMI and waist-to-hip ratio (WHR) were significantly positive correlated with periodontal pocket depth and clinical attachment level. Using a Multivariate logistic regression model, periodontitis correlates to BMI, WHR, serum levels of triglyceride, total cholesterol, low density lipoprotein, and adipokines such as visfatin, leptin, and resistin. Conclusions: Obesity is positively correlated with the aggravation of periodontitis. Obesity may aggravate the damage to periodontal tissue by regulating the secretion level of adipokines. [ABSTRACT FROM AUTHOR]
- Subjects :
- LIPID metabolism
OBESITY complications
ADIPOKINES
INTERLEUKINS
C-reactive protein
TRIGLYCERIDES
HDL cholesterol
GLYCOSYLATED hemoglobin
CYTOKINES
ACADEMIC medical centers
BODY weight
NOSOLOGY
DENTAL plaque
PERIODONTITIS
SERUM
CROSS-sectional method
LEPTIN
MULTIVARIATE analysis
INFLAMMATION
LDL cholesterol
RISK assessment
RESISTIN
WAIST-hip ratio
ADIPONECTIN
RESEARCH funding
BODY mass index
LOGISTIC regression analysis
GINGIVA
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 14726823
- Volume :
- 23
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Endocrine Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 163913562
- Full Text :
- https://doi.org/10.1186/s12902-023-01366-7