Patent Issued for Method for preparing amantadine (USPTO 11639328).

"At present, amantadine is mainly prepared by brominating adamantane to obtain a brominated adamantane, and then reacting with urea. Brominating adamantane is performed by the reaction of adamantane with bromine, during which excess bromine needs to be added, and remaining bromine after reacting needs to be removed with sodium sulfite solution. Keywords: Adamantane; Adamantane Antivirals; Amantadine Therapy; Antiinfectives; Antiparkinson Agents; Antiretrovirals; Antivirals; Bridged Compounds; Bromine; Business; Central Nervous System Agents; Chlorine; Cycloparaffins; Dopaminergic Antiparkinsonism Agents; Drugs and Therapies; Halogens; Health and Medicine; Hydrocarbons; Organic Chemicals; Pharmaceuticals; Shandong Holly Pharmaceutical Co. Ltd.; Urea EN Adamantane Adamantane Antivirals Amantadine Therapy Antiinfectives Antiparkinson Agents Antiretrovirals Antivirals Bridged Compounds Bromine Business Central Nervous System Agents Chlorine Cycloparaffins Dopaminergic Antiparkinsonism Agents Drugs and Therapies Halogens Health and Medicine Hydrocarbons Organic Chemicals Pharmaceuticals Shandong Holly Pharmaceutical Co. Ltd. Urea 2985 2985 1 05/22/23 20230522 NES 230522 2023 MAY 26 (NewsRx) -- By a News Reporter-Staff News Editor at Pharma Business Week -- Shandong Holly Pharmaceutical Co. Ltd. (Shandong, People's Republic of China) has been issued patent number 11639328, according to news reporting originating out of Alexandria, Virginia, by NewsRx editors. [Extracted from the article]