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Changes in quantity plant-based protein intake on type 2 diabetes remission in coronary heart disease patients: from the CORDIOPREV study.
- Source :
- European Journal of Nutrition; Jun2023, Vol. 62 Issue 4, p1903-1913, 11p, 4 Charts, 3 Graphs
- Publication Year :
- 2023
-
Abstract
- Purpose: Diabetes remission is a phenomenon described in the context of drastic weight loss due to bariatric surgery or low-calorie diets. Evidence suggests that increasing the intake of plant protein could reduce the risk of type 2 diabetes. We sought for association between changes in plant protein intake in the context of 2 healthy diets without weight loss nor glucose-lowering medication, and diabetes remission in coronary heart disease patients from the CORDIOPREV study. Methods: Newly diagnosed type 2 diabetes participants without glucose-lowering treatment were randomized to consume a Mediterranean or a low-fat diet. Type 2 diabetes remission was assessed with a median follow-up of 60 months according to the ADA recommendation. Information on patient's dietary intake was collected using food-frequency questionnaires. At first year of intervention, 177 patients were classified according to changes in plant protein consumption into those who increased or decreased its intake, in order to perform an observational analysis on the association between protein intake and diabetes remission. Results: Cox regression showed that patients increasing plant protein intake were more likely to remit from diabetes than those who decreased its intake (HR = 1.71(1.05–2.77)). The remission occurred mainly at first and second year of follow-up with diminished number of patients achieving remission in the third year onwards. The increase in plant protein was associated with lower intake of animal protein, cholesterol, saturated fatty acids, and fat, and with higher intake of whole grains, fibre, carbohydrates, legumes, and tree nuts. Conclusion: These results support the need to increase protein intake of vegetal origin as dietary therapy to reverse type 2 diabetes in the context of healthy diets without weight loss. [ABSTRACT FROM AUTHOR]
- Subjects :
- STATINS (Cardiovascular agents)
MEDITERRANEAN diet
FOOD habits
DIETARY fiber
STATISTICS
GLYCOSYLATED hemoglobin
C-reactive protein
HDL cholesterol
TRIGLYCERIDES
HYPERTENSION
NUTRITIONAL assessment
LEGUMES
FOOD consumption
ANTHROPOMETRY
DIETARY cholesterol
SATURATED fatty acids
CHEMILUMINESCENCE assay
BLOOD plasma
ONE-way analysis of variance
AGE distribution
CORONARY disease
BLOOD sugar
LDL cholesterol
MANN Whitney U Test
PLANT proteins
TYPE 2 diabetes
LOW-fat diet
TREATMENT effectiveness
RANDOMIZED controlled trials
FOOD animals
IMMUNOASSAY
SEX distribution
T-test (Statistics)
QUESTIONNAIRES
DESCRIPTIVE statistics
ENZYME-linked immunosorbent assay
REPEATED measures design
CHI-squared test
KAPLAN-Meier estimator
WAIST circumference
ALCOHOL drinking
APOLIPOPROTEINS
RESEARCH funding
STATISTICAL sampling
DATA analysis software
GRAIN
DIETARY carbohydrates
BLOOD pressure measurement
DATA analysis
SMOKING
BODY mass index
DIETARY proteins
DISEASE remission
PROPORTIONAL hazards models
VENOUS puncture
LONGITUDINAL method
NUTS
DIETARY fats
FAMILY history (Medicine)
INSULIN resistance
ALANINE aminotransferase
Subjects
Details
- Language :
- English
- ISSN :
- 14366207
- Volume :
- 62
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- European Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 163798173
- Full Text :
- https://doi.org/10.1007/s00394-022-03080-x