Toxicity with proton therapy for oral and/or oropharyngeal cancers.

Based on these findings, the authors concluded that their review confirms that patients undergoing PT for oral and/or oropharyngeal cancer had sustained treatment outcomes with a vastly better acute toxicity profile. Second, although the ORNJ has been presented as one of the acute PT toxicities by Sethi et al.,[1] it is typically a late-onset complication of RT since it usually manifests after 6-months of RT in the absence of predisposing risk factors like previous mandibular surgery. First, RT-associated toxicity is classified according to time following treatment: acute toxicity occurs during or within 6 weeks to 3 months of therapy completion; early-delayed (subacute) toxicity appears up to 6 months after treatment completion; and late effects are present at least 6 months after therapy completion. [Extracted from the article]