Air Pollution and Perinatal Mental Health: A Comprehensive Overview.

Background: The aim of the present study was to summarise the available data about the link between air pollution exposure and the new-onset and severity of psychiatric disorders in pregnant women during the perinatal period. Materials and methods: We selected articles published until June 2022 on PubMed and the Web of Science. Pollutants included were PM_2.5 (particulate matter 2.5 micrometres and smaller), PM₁₀ (particulate matter 10 micrometres and smaller), NO₂ (nitrogen dioxide), O₃ (ozone), SO₂ (sulphur dioxide), CO (carbon monoxide), PBDEs (polybrominated diphenyl ethers), PFAS (per- and polyfluoroalkyl substances), lead, and cadmium. The perinatal period was considered as the time of pregnancy until one year after childbirth. Results: Nine studies were included; most of them evaluated the association between exposure to air pollutants and the onset of Postpartum Depression (PPD). Two studies showed an association between, respectively, only PM_2.5 and both PM_2.5 and NO₂ exposure and PPD onset 12 months after childbirth, while another study found a significant association between NO₂ exposure and PPD occurrence 6 months after childbirth. PBDE blood levels were associated with more severe depressive symptoms. Lastly, one study observed a link between stressful symptoms and exposure to PM_2.5, PM₁₀ during pregnancy. Conclusion: More comprehensive and uniform studies are required to make a roadmap for future interventions, given the growing relevance of issues such pollution and mental health, particularly during the perinatal period. [ABSTRACT FROM AUTHOR]