"Compositions And Methods For Enhancing Differentiation Of Stem Cell-Derived Beta Cells" in Patent Application Approval Process (USPTO 20230128770).

The methods comprise contacting at least one endocrine progenitor cell during a beta cell differentiation protocol with a YAP modulator, wherein the at least one endocrine progenitor cell differentiates into at least one stem cell-derived beta cell. In some embodiments, the population comprises a 2-fold to 3-fold reduction in proliferative progenitor cells (e.g., SOX9+ ductal like proliferative progenitor cells and/or Ki67+ proliferative cells), as compared to a control sample "Disclosed herein are methods comprising modulating YAP expression during a beta cell differentiation protocol. A method of producing a stem cell-derived beta cell comprising contacting at least one endocrine progenitor cell during a beta cell differentiation protocol with a YAP modulator, wherein the at least one endocrine progenitor cell differentiates into at least one stem cell-derived beta cell. Keywords: Cell Differentiation; Endocrine Research; Genetics; Health and Medicine; Patent Application; Peptide Hormones; Peptide Proteins; Proinsulin; Stem Cell Research EN Cell Differentiation Endocrine Research Genetics Health and Medicine Patent Application Peptide Hormones Peptide Proteins Proinsulin Stem Cell Research 656 656 1 05/15/23 20230519 NES 230519 2023 MAY 15 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- A patent application by the inventors Melton, Douglas A. (Cambridge, MA, US); Rosado-Olivieri, Edwin (Somerville, MA, US), filed on March 31, 2020, was made available online on April 27, 2023, according to news reporting originating from Washington, D.C., by NewsRx correspondents. [Extracted from the article]