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A hypoxia-activatable theranostic agent with intrinsic endoplasmic reticulum affinity and type-I photosensitivity.
- Source :
- Journal of Materials Chemistry B; 5/14/2023, Vol. 11 Issue 18, p4102-4110, 9p
- Publication Year :
- 2023
-
Abstract
- A unique photosensitizer (PS), <superscript>ER</superscript>PS, with intrinsic endoplasmic reticulum (ER)-targeting ability and low oxygen-depletion type-I photosensitivity, is developed and used as a scaffold to construct an activatable theranostic agent for precise photodynamic therapy (PDT). The ER-targeted feature coupled with type-I photosensitivity endows <superscript>ER</superscript>PS with high phototoxicity toward tumor cells under both normoxic and hypoxic conditions. In addition, caging the phenol group of <superscript>ER</superscript>PS with a nitroreductase-sensitive triggering group provided a hypoxia-activatable PS (<superscript>ER</superscript>PSIm) that is encapsulated within a polymeric micelle to obtain a water-stable Im@NP nanoparticle for in vivo applications. After intravenous administration to 4T1 tumor-bearing BALB/c mice, Im@NP demonstrated highly efficient imaging-guided PDT ablation of implanted tumors. This is because the delivered <superscript>ER</superscript>PSIm cargos of Im@NP are specifically activated in the hypoxic microenvironment of solid tumor, and the activated <superscript>ER</superscript>PS molecules have efficient ER-targeted type-I photosensitivity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2050750X
- Volume :
- 11
- Issue :
- 18
- Database :
- Complementary Index
- Journal :
- Journal of Materials Chemistry B
- Publication Type :
- Academic Journal
- Accession number :
- 163636027
- Full Text :
- https://doi.org/10.1039/d3tb00328k