Effects of ambient air pollution on outpatient visits for psoriasis in Wuhan, China: a time-series analysis.

Background Psoriasis can be provoked by both external and internal factors. The effects of environmental factors on psoriasis remain unclear. Objectives To investigate the effects of air pollution on outpatient visits for psoriasis. Methods A distributed lag nonlinear model following quasi-Poisson regression was used to evaluate the lag effects of air pollutants on psoriasis outpatient visits, adjusting for potential confounders. Stratified analyses were performed to identify potential effect modifications by sex, age and season. Results In total, 13 536 outpatient visits for psoriasis were recorded in Wuhan, China from 1 January 2015 to 31 December 2019. In the single-pollutant model, exposures to particulate matter (PM) smaller than 2.5 μm (PM_2.5), PM smaller than 10 μm (PM₁₀), NO₂ and SO₂ were found to be significantly associated with increased daily psoriasis outpatient visits. For the largest effects, a 10-μg m⁻³ increase in concentrations of PM_2.5 (lag1), PM₁₀ (lag1), NO₂ (lag0) and SO₂ (lag3) corresponded to 0.32% [95% confidence interval (CI) 0.01–0.63], 0.26% (95% CI 0.05–0.48), 0.98% (95% CI 0.01–1.96) and 2.73% (95% CI 1.01–4.47) increases in psoriasis outpatient visits, respectively. In the two-pollutant model, only NO₂ showed significant and stable effects on the outpatient visits for psoriasis. Conclusions Ambient air pollution, especially NO₂, appears to be significantly associated with an increased risk of outpatient visits for psoriasis in Wuhan, China. Air pollution control and exposure prevention could be effective measures to relieve the symptoms of psoriasis among these patients. [ABSTRACT FROM AUTHOR]