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Hypothesis: inflammatory acid-base disruption underpins Long Covid.
- Source :
- Frontiers in Immunology; 4/28/2023, p01-05, 5p
- Publication Year :
- 2023
-
Abstract
- The mechanism of Long Covid (Post-Acute Sequelae of COVID-19; PASC) is currently unknown, with no validated diagnostics or therapeutics. SARS-CoV-2 can cause disseminated infections that result in multi-system tissue damage, dysregulated inflammation, and cellular metabolic disruptions. The tissue damage and inflammation has been shown to impair microvascular circulation, resulting in hypoxia, which coupled with virally-induced metabolic reprogramming, increases cellular anaerobic respiration. Both acute and PASC patients show systemic dysregulation of multiple markers of the acid-base balance. Based on these data, we hypothesize that the shift to anaerobic respiration causes an acid-base disruption that can affect every organ system and underpins the symptoms of PASC. This hypothesis can be tested by longitudinally evaluating acid-base markers in PASC patients and controls over the course of a month. If our hypothesis is correct, this could have significant implications for our understanding of PASC and our ability to develop effective diagnostic and therapeutic approaches. [ABSTRACT FROM AUTHOR]
- Subjects :
- POST-acute COVID-19 syndrome
THERAPEUTICS
CELL respiration
COVID-19
HYPOTHESIS
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Database :
- Complementary Index
- Journal :
- Frontiers in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 163484842
- Full Text :
- https://doi.org/10.3389/fimmu.2023.1150105