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Antigen-specificity measurements are the key to understanding T cell responses.
- Source :
- Frontiers in Immunology; 4/28/2023, p01-18, 18p
- Publication Year :
- 2023
-
Abstract
- Antigen-specific T cells play a central role in the adaptive immune response and come in a wide range of phenotypes. T cell receptors (TCRs) mediate the antigen-specificities found in T cells. Importantly, high-throughput TCR sequencing provides a fingerprint which allows tracking of specific T cells and their clonal expansion in response to particular antigens. As a result, many studies have leveraged TCR sequencing in an attempt to elucidate the role of antigen-specific T cells in various contexts. Here, we discuss the published approaches to studying antigen-specific T cells and their specific TCR repertoire. Further, we discuss how these methods have been applied to study the TCR repertoire in various diseases in order to characterize the antigen-specific T cells involved in the immune control of disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
T cell receptors
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Database :
- Complementary Index
- Journal :
- Frontiers in Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 163484832
- Full Text :
- https://doi.org/10.3389/fimmu.2023.1127470