Optimization of molecularly imprinted polymers (MIPs) microsphere absorption for uric acid.

Molecularly Imprinted Polymers (MIPs) are artificial sorbents that have cavity that can absorb target molecules with very high selectivity and sensitivity. The purpose of this research was to produce MIPs microsphere as uric acid absorbers by photopolymerization method using Ultra-Violet light as a free radical activator. The results showed that the synthesized MIPs microsphere succeeded to absorb uric acid as shown in the results of the FTIR analysis. The FTIR spectra showed that there was no N-H peak in MIPs microsphere, while the MIPs re-extraction microsphere had a C-N absorption peak at 1142.84 cm⁻¹. The C-N functional group was the group found in uric acid. Analysis of uric acid absorption by MIPs used UV-Vis spectrophotometer for uric acid in solution and Easy-Touch for uric acid in the blood. At optimum conditions (amount of MIPs microsphere was 0.08 grams, pH of the uric acid solution 7.57 with 24 hours), the percentage of absorption produced is 47.9% for uric acid in solution, while the percentage of MIPs absorption in the blood is 20.33%. The results of the research show that the MIPs microsphere can absorb uric acid. [ABSTRACT FROM AUTHOR]