Effect of carbon nanotubes on metabolism and oxidative stress response in spontaneously hypertensive rat model.

Cardiovascular disease has become one of the highest mortality diseases in the world. Single walled carbon nanotubes have acute effects on the muscles and lungs of spontaneously hypertensive rats. Inhalation of multi walled carbon nanotubes can cause subchronic injury to the muscles of the rats. Spontaneously hypertensive rats (SHR) are a good animal model of cardiovascular diseases, which exhibit similar properties to human hypertension. Therefore, in this study, the effects of carbon nanotubes on metabolism and oxidative stress in spontaneously hypertensive rats were studied. The results show that the early structural changes of cardiovascular tissue are independent of the formation of blood pressure, and there can be non-stress factors, leading to excessive structural remodeling. In group H and group L, the model of SHR rats was not passed after 7 days of administration, indicating that the two kinds of carbon nanotubes have little stimulation on SHR rats. After 30 days of administration, all the models failed, indicating that carbon nanotubes had no obvious chronic toxicity to cardiac metabolism in SHR rats. The increase of no content in SHR may be the mechanism of increased systolic blood pressure. The increase of iNOS and no in plasma may be related to the enhancement of oxidative stress after exposure to carbon nanotubes. [ABSTRACT FROM AUTHOR]