Study on Gene Splicing Site Recognition Based on Particle Swarm Optimization Twin Support Vector Machine Algorithm for Smart Healthcare.

Gene splicing site recognition is a very important research topic in smart healthcare. Gene splicing site recognition is of great significance, not only for the large-scale and high-quality computational annotation of genomes but also for the analysis and recognition of the gene sequences evolutionary process. It is urgent to study a reliable and effective algorithm for gene splice site recognition. Traditional Twin Support Vector Machine (TWSVM) algorithm has advantages in solving small-sample, nonlinear, and high-dimensional problems, but it cannot deal with parameter selection well. To avoid the blindness of parameter selection, particle swarm optimization algorithm was used to find the optimal parameters of twin support vector machine. Therefore, a Particle Swarm Optimization Twin Support Vector Machine (PSO-TWSVM) algorithm for gene splicing site recognition was proposed in this paper. The proposed algorithm was compared with traditional Support Vector Machine algorithm, TWSVM algorithm, and Least Squares Support Vector Machine algorithm. The comparison results show that the positive sample recognition rate, negative sample recognition rate, and correlation coefficient (CC) of the proposed algorithm are the best among the four different support vector machine algorithms. The proposed algorithm effectively improves the recognition rate and the accuracy of splice sites. The comparison experiments verify the feasibility of the proposed algorithm. [ABSTRACT FROM AUTHOR]