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A cross-sectional study of the levels of cytokines IL-6, TNF-α, and IFN-γ in blood and skin (lesional and uninvolved) of vitiligo patients and their possible role as biomarkers.

Authors :
De, Abhishek
Choudhary, Nidhi
Sil, Amrita
Sarda, Aarti
Hasanoor Raja, Abu
Source :
Indian Journal of Dermatology; Jan/Feb2023, Vol. 68 Issue 1, p67-72, 6p
Publication Year :
2023

Abstract

Introduction: Vitiligo is a multifactorial disorder, most often explained by the autoimmune hypothesis. The objective of this study is to measure the levels of cytokines IL-6, TNF-α, and IFN-γ in the blood and skin (lesional and uninvolved) of vitiligo patients and to compare it with that of age-matched controls. Methods: IL-6, TNF-alpha, and IFN-gamma cytokines were measured with a BioRad 6110 ELISA reader. We compared the levels of these cytokines in generalized versus localized vitiligo and stable versus unstable vitiligo. We also correlated cytokine levels in blood/lesion/uninvolved skin with body surface area (BSA) involvement and Vitiligo Disease Activity (VIDA) scoring. Result: Forty-three participants, each with vitiligo and control, were analyzed. The values of TNF-α and IL 6 in sera were significantly higher in the vitiligo group compared with the controls (p < 0.001), whereas INF-γ was significantly lower in the vitiligo group than the control group. TNF-α, INF-γ levels when compared between blood, lesional skin, and normal skin in all vitiligo patients were found to be significant (p < 0.001). Conclusion: We conclude vitiligo is strongly associated with increased levels of TNF-α and IL 6. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00195154
Volume :
68
Issue :
1
Database :
Complementary Index
Journal :
Indian Journal of Dermatology
Publication Type :
Academic Journal
Accession number :
163293911
Full Text :
https://doi.org/10.4103/ijd.ijd_27_22