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Anti‐SARS‐CoV‐2 spike immunoglobulin G and immunoglobulin M titers decline as interval from the second inactivated vaccine dose to the onset of illness is prolonged in breakthrough infection patients.
- Source :
- Clinical Respiratory Journal; Apr2023, Vol. 17 Issue 4, p270-276, 7p
- Publication Year :
- 2023
-
Abstract
- Background: Understanding of the early immune response in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) breakthrough infections is limited. Methods: Ninety‐eight patients with coronavirus disease 2019 (COVID‐19) breakthrough infections were divided into two groups, with intervals from receiving the second dose of inactivated vaccine to the onset of illness <60 or ≥60 days. Results: The median lymphocyte count and the median anti‐SARS‐CoV‐2 spike immunoglobulin G (IgG) and immunoglobulin M (IgM) titers were higher in the <60‐day interval group compared with the corresponding medians in the ≥60‐day interval group (p = 0.005, p = 0.001, and p = 0.001, respectively). The median interleukin‐6 (IL‐6) level in the <60‐day interval group was significantly lower than the median IL‐6 level in the ≥60‐day interval group (p < 0.001). Conclusions: Our results highlight the different anti‐SARS‐CoV‐2 spike IgG and IgM antibody titers among patients with different intervals from receiving the second dose of inactivated vaccine to the onset of illness. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17526981
- Volume :
- 17
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Clinical Respiratory Journal
- Publication Type :
- Academic Journal
- Accession number :
- 163190075
- Full Text :
- https://doi.org/10.1111/crj.13590