The innovative 52gMn for positron emission tomography (PET) imaging: Production cross section modeling and dosimetric evaluation.

Background: Manganese is a paramagnetic element suitable for magnetic resonance imaging (MRI) of neuronal function. However, high concentrations of Mn²⁺ can be neurotoxic. ^52gMn may be a valid alternative as positron emission tomography (PET) imaging agent, to obtain information similar to that delivered by MRI but using trace levels of Mn²⁺, thus reducing its toxicity. Recently, the reaction ^natV(α,x)^52gMn has been proposed as a possible alternative to the standard ^natCr(p,x)^52gMn one, but improvements in the modeling were needed to better compare the two production routes. Purpose: This work focuses on the development of precise simulations and models to compare the ^52gMn production from both reactions in terms of amount of activity and radionuclidic purity (RNP), as well as in terms of dose increase (DI) due to the co-produced radioactive contaminants, versus pure ^52gMnCl₂. Methods: The nuclear code Talys has been employed to optimize the ^natV(α,x)^52gMn cross section by tuning the parameters of the microscopic level densities. Thick-target yields have been calculated from the expression of the rates as energy convolution of cross sections and stopping powers, and finally integrating the time evolution of the relevant decay chains. Dosimetric assessments of [xxMn]Cl₂ have been accomplished with OLINDA software 2.2.0 using female and male adult phantoms and biodistribution data for ^52gMnCl₂ in normal mice. At the end, the yield of xxMn radioisotopes estimated for the two production routes have been combined with the dosimetric results, to assess the DI at different times after the end of the irradiation. Results: Good agreement was obtained between cross-section calculations and measurements.The comparison of the two reaction channels suggests that ^natV(α,x)^52gMn leads to higher yield and higher purity,resulting inmore favorable radiation dosimetry for patients. Conclusions: Both ^natV(α,x) and ^natCr(p,x) production routes provide clinically acceptable ^52gMnCl₂ for PET imaging. However, the ^natV(α,x)^52gMn reaction provides a DI systematically lower than the one obtainable with ^natCr(p,x)^52gMn and a longer time window in which it can be used clinically (RNP ≥ 99%). [ABSTRACT FROM AUTHOR]