Design and modeling of an angular interrogation based surface plasmon resonance biosensor for dengue virus detection.

This article presents a hybrid Au/BatiO₃/WSe₂-based surface plasmon resonance (SPR) biosensor for detecting the dengue virus. The sensing surface of the proposed biosensor is immobilized with different healthy and infected blood cells such as plasma, platelet, and hemoglobin. The angular interrogation method is used to investigate the detection performance of the biosensor. The design and performance analysis of the biosensor is conducted by using the finite-difference time-domain (FDTD) method. The impacts of different nanomaterials including BatiO₃ and WSe₂ on the performance parameters are investigated and analyzed numerically. The numerical analysis involves the use of a FDTD in a multiphysics platform to determine the effect of different nanomaterials on the performance parameters, such as sensitivity, detection accuracy and quality factor. This numerical analysis allows for the comparison of the different nanomaterials and the determination of which is most suitable for the particular application. Results from the investigation and analysis show that these nanomaterials can effectively enhance the performance of the proposed biosensor which can provide valuable insights into the effective design of the biosensor. In addition, electric field distribution and magnetic field propagation for resonance and non-resonance conditions are determined for the biosensor in which an enhanced electric field is observed at the metallic layer. This enhanced electric field is caused by the metallic layer acting as a reflector and redirecting the electric field, increasing the concentration of electric field lines in the vicinity of the metallic layer. This increased electric field concentration leads to increased sensitivity and detection accuracy of the biosensor. The proposed biosensor offers a maximum angular shift of 128.571 deg/RIU, a quality factor of 230.7 RIU⁻¹, and a detection accuracy of 4.5 for dengue virus detection through dengue-infected blood cells. The output parameters of the proposed biosensor are compared with the reported biosensors and found to be superior to them. [ABSTRACT FROM AUTHOR]